Collagen has become so popular in recent years because of its incredible benefits. The reasons why headaches are a potential side effect of collagen are variable and not necessarily conclusive, as more research is needed on this topic., However, one common trend we found in our research for this article is that the type of collagen and quality of the supplement itself contributes a lot to the potential for side effects like headaches., It has been considered that collagen may cause headaches for some users because it can raise your calcium levels. Would you like email updates of new search results? Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. Webcan collagen supplements cause headaches? Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. PMC Lim, S. H., Sun, Y., Thiruvallur Madanagopal, T., Rosa, V., & Kang, L. (2018). 7 Weird, Harmful Collagen Side Effects You Need To Know WebGlutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Type 2: This is present primarily in cartilage and can help promote joint health. 2013;77(4):691-6. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. 2019;17(3). Can Zdzieblik D, Brame J, Oesser S, Gollhofer A, Knig D. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Prokopov A, Pavlackov J, Mokrejs P, Gl R. Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation. Kumar S, Sugihara F, Suzuki K, Inoue N, Venkateswarathirukumara S. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. 2014;27(3):113-9. Dizziness. Similar to vegan options, a person may want to look for a collagen supplement that specifically aims to support the keto diet. Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. View abstract. Nutrition is a key factor influencing skin health and consequently its appearance. Hakuta A, Yamaguchi Y, Okawa T, Yamamoto S, Sakai Y, Aihara M. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. -CTX and P1NP were unaffected by CP supplementation (P > 0.05). Copper Peptides Best overall collagen supplement: Vital Proteins Collagen Peptides. National Library of Medicine The role of glutamate and its receptors in migraine. Clipboard, Search History, and several other advanced features are temporarily unavailable. View abstract. View abstract. Drugs. Our team thoroughly researches and evaluates the recommendations we make on our site. It may help hydrate your skin. 2022 Dec 17;12(12):1283. doi: 10.3390/metabo12121283. Sci Rep. 2022 Jun 13;12(1):9804. doi: 10.1038/s41598-022-14068-2. Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. 2020;20(1):12-17.View abstract. Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. View abstract. Most collagen users do not experience any adverse effects when taking a high-quality collagen supplement at the proper dosage., The source of the collagen is also a huge factor in whether or not collagen can cause headaches and other side effects., For instance, many bone broth based collagen supplements are very high in sodium and potassium, not to mention the collagen in that type of supplement is harder to digest.. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: a randomized controlled trial. Sports Med. 2016;96(12):4077-81. Koizumi S, Inoue N, Sugihara F, Igase M. Effects of collagen hydrolysates on human brain structure and cognitive function: A pilot clinical study. Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Bauza E, Oberto G, Berghi A, Dal CF, Domloge N. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. 2012;60(16):4096-4101. The two most commonly proposed benefits of collagen peptides are improved skin health and reduced joint pain. Saiga-Egusa A, Iwai K, Hayakawa T, Takahata Y, Morimatsu F. Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension. But these supplements are also touted to support digestion and heart health, prevent bone loss and increase muscle mass. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Bethesda, MD 20894, Web Policies For most people, taking collagen peptide supplements should not have any major effects or health consequences, and topical collagen peptide products in particular are unlikely to pose a risk. In studies, collagen peptide supplements have been shown to support skin elasticity 5 and overall hydration 6 . Expert Opin Investig Drugs. Always take your collagen peptide supplements as instructed by a healthcare professional or as directed on the label of a product. Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects. Before Some peptides are antimicrobial, meaning they can kill Many are available to buy online. Reducing the stiffness of arteries can help promote heart health. Metabolites. 2008 May;144(5):666-72. doi: 10.1001/archderm.144.5.666. Methods: There are also claims that collagen may help prevent skin conditions such as acne. Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies. Collagen supplements may help support skin, hair, and joint health. But does collagen have any side effects, and can collagen cause headaches?. However, more research is necessary to prove the effects of collagen in supporting heart health. 2009;73(2):422-4. Unable to load your collection due to an error, Unable to load your delegates due to an error. A person can also use collagen supplements while following a keto diet plan. You can learn more about how we ensure our content is accurate and current by reading our. That being said, we want to point out that these side effects are not common. Read on to learn more about L-tryptophan, including its safety and efficacy. Some collage supplements do source from these animals, so when taking them, youre likely to have an allergic reaction of some kind., The question of whether collagen can cause headaches or not is somewhat subjective, but the short answer is yes. Collagen supplementation as a complementary therapy for the prevention and treatment of osteoporosis and osteoarthritis: A systematic review. Although they are most popularly used to combat the signs of aging in the skin, collagen peptides can provide a number of other potential benefits as well. Nutrients. Wauquier F, Boutin-Wittrant L, Bouvret E, Le Faouder J, Roux V, Macian N, Pickering G, Wittrant Y. Nutrients. WebCollagen comprises about 60% of cartilage, a very firm tissue that surrounds bones and cushions them from the shock of high-impact movements; so a breakdown in collagen could lead to a loss of cartilage and joint problems. View abstract. If you take too much collagen, it can throw off the balance of amino acids in your body and lead to side effects such as headaches, digestive issues, and fatigue. 2022 Nov 25;14(23):5027. doi: 10.3390/nu14235027. and transmitted securely. Lampropoulou-Adamidou K, Karlafti E, Argyrou C, et al. 2010;65(3):253-7. 2019;12(1):50. If you buy through links on this page, we may earn a small commission Heres our process. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Kim HY, Lee JD, Lee YH, Seo SW, Lee HS, Kim S, Kim KB. Lis DM, Jordan M, Lipuma T, Smith T, Schaal K, Baar K. Collagen and Vitamin C Supplementation Increases Lower Limb Rate of Force Development. View abstract. View abstract. Oxid Med Cell Longev. Creams have the advantage of providing extra hydration, making them particularly suitable for dry, wrinkled, or aging skin, and they pose even fewer risks than the already rare potential side effects of oral supplements. Epub 2013 Dec 24. 2018 Dec 28;7(1):5. doi: 10.3390/sports7010005. 2017;24(13):1332-1349. doi: 10.2174/0929867324666170227115019. WebAutoimmune diseases (your bodys immune system attacks its own tissue) can damage collagen. View abstract. sharing sensitive information, make sure youre on a federal 2021 Jan 1;31(1):32-39. doi: 10.1123/ijsnem.2020-0149. Trc T, Bohmov J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Subscribe to get special offers, free giveaways, and once-in-a-lifetime deals. 2021;20(3):825-834. Also, in many cases, the collagen is hydrolyzed. Int J Dermatol 2021;60(12):1449-1461. A pilot study for the detection of cyclic prolyl-hydroxyproline (Pro-Hyp) in human blood after ingestion of collagen hydrolysate. However, the likelihood of a headache due to collagen may be minimal in comparison to the many, , like ProT Gold, are easier to digest because the molecules are smaller and easier for your body to break down., Bariatric Surgery Recovery Time: What To Expect & When You Can Get Back to Work, 35 Bariatric-Friendly Snacks To Eat After Surgery, The Pre Gastric Bypass Diet: What To Eat and Drink, How To Shorten Gastric Bypass Recovery Time: 7 Simple Tips. Still, the only real risk with collagen is knowing the source, quality, and reliability of the supplement company., It is important to get to know the company you are buying a supplement from and to ensure that they are transparent about all of their ingredients and product sourcing., If the company is not transparent, and you have no idea what is in the supplement, there is a higher chance the collagen can cause headaches and other issues., Beyond the product itself and ingredients, dosage can also impact how safe it is to use collagen as a daily supplement., As with anything, it is possible to take too much and have an adverse reaction. J Cosmet Dermatol. 2016;39(3):428-34. COLLAGEN PEPTIDES - Uses, Side Effects, and More The researchers theorized that collagen helped stimulate the production of the proteins responsible for muscle growth. Maia Campos PMBG, Franco RSB, Kakuda L, Cadioli GF, Costa GMD, Bouvret E. Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study. View abstract. Collagen benefits for skin and hair.*. and transmitted securely. A 2016 animal study also found that collagen hydrolysate (also called collagen peptides) reduced fat cell size and weight gain in rats. Also, as with any supplement, the Food and Drug Administration (FDA) do not evaluate any claims that a company makes on how well their collagen product works. View abstract. Unauthorized use of these marks is strictly prohibited. J Cosmet Dermatol. Given that glutamic acid is one of the amino acids present in the collagen protein, eating too many collagen peptides may indirectly lead to an unwanted headache. Accessibility doi: 10.1002/brb3.2820. Collagen supplements are available in the form of tablets, capsules, and powders. eCollection 2022 Aug. FOIA Our aim was to investigate the effect of oral supplementation with specific collagen peptides on skin hydration and the dermal collagen network in a clinical setting. In rare cases, a peptide allergy can occur. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. In particular, the spongy cartilage of the joints starts to wear away. Does Collagen Make You Poop More? ANSWERED 2020;72(3):125-130. However, some of the potential health benefits of collagen supplements include: Some people who take collagen supplements are looking to improve the look and overall health of their skin. 5 Collagen Side Effects You Need to Know About by Zen Principle Type of ingredient: Hydrator and strengthener 4. Collagen is the most important structural protein in the body, critical to skin firmness, elasticity, and an overall youthful appearance. Conclusion: These symptoms are usually mild and resolve on their own. While we have no reports of ProT Gold users experiencing headaches or migraines after using our collagen products, preliminary research into the topic suggests that there may be a correlation between some collagen supplements and headaches., Whether collagen can cause headaches or not often is dependent on the person taking the supplement, the dosage, the type of collagen, and the supplement quality itself., If you suspect that your supplemental collagen can cause headaches or migraines, then exploring why you have this reaction and how to prevent it will be the first place to start., Before we get into whether collagen can cause headaches, lets look at the overall safety of collagen supplements in general., If youre asking the question: can collagen cause headaches? You are probably also interested in other possible side effects of collagen, and if collagen is a safe supplement to take., Its hard to answer whether collagen can cause headaches and if the supplement itself is safe, simply because the FDA does not regulate most supplements., Since there is such limited regulation of supplements on the market, this leads to immense skepticism regarding how safe they really are and what side effects they cause., The lack of regulation when it comes to supplements versus drugs means that not all supplement companies necessarily have to prove their claims., So, if they are simply trying to sell a product to the consumer, they do not have to have evidence to support whether or not the collagen supplement they are providing actually will benefit the consumer, or whether their supplemental collagen can cause headaches or other issues., Still, the FDA does recognize ingestible collagen as Generally Recognized As Safe (GRAS)., There have been specific collagen supplements that have been recalled by the FDA for safety reasons, which is why it is important to buy from a reputable brand., For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a nutritional label, not a supplement label., Because of this, ProT Gold is also trusted by over 3,000 medical facilities and used widely for medical nutrition therapy., Something that should be recognized about collagen as a supplement is that it is natural. Apart from fatigue, this might lead to headaches and feelings of nervousness and irritability. Complementary Medicine / Alternative Medicine, http://www.jmnn.org/article.asp?issn=2278-1870;year=2015;volume=4;issue=1;spage=47;epage=53;aulast=Borumand, https://www.versusarthritis.org/about-arthritis/complementary-and-alternative-treatments/types-of-complementary-treatments/collagen/, https://www.ncbi.nlm.nih.gov/pubmed/25314004, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793325/, http://www.scielo.br/pdf/rbgg/v19n1/1809-9823-rbgg-19-01-00153.pdf, https://www.ncbi.nlm.nih.gov/pubmed/23949208, https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12450, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429168/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594048/.

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